Endocrine Abstracts

Background: GH potently stimulates collagen turnover which underlies its anabolic effects on bone in children, whereas it may promote fibrosis in adults. Fibroblast activation protein-α (FAPα) is involved in collagen turnover by its collagen-cleaving and fibroblast-stimulating activity, which predominantly is expressed in association with fibrosis. FAPα also cleaves and inactivates fibroblast growth factor 21 (FGF21), a multi-faceted metabolic hormone. We have p...